کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1372925 | 981886 | 2011 | 4 صفحه PDF | دانلود رایگان |
A new rare 20-membered macrocyclic lactam incorporating a diene conjugated olefin, designated sannastatin (1), together with the known structurally related vicenistatin (2), has been isolated from the cultures of Streptomyces sannanensis, a bacteria found in the feces of Ailuropoda melanoleuca. The structure of the new compound was established on the basis of extensive spectroscopic analyses including 1D- and 2D-NMR (1H–1H COSY, TOCSY, HSQC, HMBC, and NOESY) experiments. Compounds 1 and 2 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina) larvae.
A new rare 20-membered macrocyclic lactam sannastatin (1), together with the known analogue vicenistatin (2), was isolated from the cultures of Streptomyces sannanensis found in the feces of Ailuropoda melanoleuca. Compounds 1 and 2 exhibited significant growth inhibitory activity against Artemia salina.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 13, 1 July 2011, Pages 3905–3908