Synthesis and screening of (E)-1-(β-d-galactopyranosyl)-4-(aryl)but-3-ene-2-one against Mycobacterium tuberculosis

A series of galactose-derived aryl enones were synthesised and screened against Mycobacterium tuberculosis H37Rv. Preliminary results were promising with MIC values in the range 1.56–12.5 μg/mL.

A series of galactose-derived aryl enones were synthesized as potential cell wall biosynthesis inhibitors and screened against Mycobacterium tuberculosis H37Rv. Results are promising with MIC values in the range 1.56–12.5 μg/mL.Figure optionsDownload as PowerPoint slide