کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1372995 | 981887 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tryptanthrin derivatives as Toxoplasma gondii inhibitors—structure–activity-relationship of the 6-position
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tryptanthrin derivatives as Toxoplasma gondii inhibitors—structure–activity-relationship of the 6-position Tryptanthrin derivatives as Toxoplasma gondii inhibitors—structure–activity-relationship of the 6-position](/preview/png/1372995.png)
چکیده انگلیسی
A panel of derivatives of the natural product tryptanthrin was synthesized and screened for its in vitro activity against the intracellular parasite Toxoplasma gondii. We concentrated on the modification of the 6-keto group of tryptanthrin and prepared a series of oximes, hydrazones and alcohols based on tryptanthrin. We evaluated parasite growth inhibition and host cell cytotoxicity. Our results indicate that in particular alcohol analogs are promising candidates for further investigation.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 4, 15 February 2013, Pages 1032–1035
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 4, 15 February 2013, Pages 1032–1035
نویسندگان
Bogdana Krivogorsky, Amber C. Nelson, Kelsi A. Douglas, Peter Grundt,