کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372995 981887 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tryptanthrin derivatives as Toxoplasma gondii inhibitors—structure–activity-relationship of the 6-position
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Tryptanthrin derivatives as Toxoplasma gondii inhibitors—structure–activity-relationship of the 6-position
چکیده انگلیسی

A panel of derivatives of the natural product tryptanthrin was synthesized and screened for its in vitro activity against the intracellular parasite Toxoplasma gondii. We concentrated on the modification of the 6-keto group of tryptanthrin and prepared a series of oximes, hydrazones and alcohols based on tryptanthrin. We evaluated parasite growth inhibition and host cell cytotoxicity. Our results indicate that in particular alcohol analogs are promising candidates for further investigation.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 4, 15 February 2013, Pages 1032–1035
نویسندگان
, , , ,