کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373028 981888 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhaled adenosine A2A receptor agonists for the treatment of chronic obstructive pulmonary disease
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Inhaled adenosine A2A receptor agonists for the treatment of chronic obstructive pulmonary disease
چکیده انگلیسی

COPD is a major cause of mortality in the western world. A2A agonists are postulated to reduce the lung inflammation that causes COPD. The cardiovascular effects of A2A agonists dictate that a compound needs to be delivered by inhalation to be therapeutically useful. A strategy of minimizing side-effect liability by maximizing systemic clearance was followed and pharmacological and pharmacokinetic SAR of a series of inhaled A2A agonists described. A sevenfold improvement in potency and 150-fold reduction in side-effect liability over the lead compound CGS-21680, were obtained.

The pharmacological and pharmacokinetic SAR of a series of inhaled A2A agonists for the treatment of chronic obstructive pulmonary disease is described.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 4, 15 February 2008, Pages 1284–1287
نویسندگان
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