Potent, selective MCH-1 receptor antagonists

This paper describes the lead optimization of a new series of potent, selective, orally bioavailable, brain-penetrant MCH-1 receptor antagonists. A major focus of the work was to achieve a selectivity profile appropriate for in vivo efficacy studies and safety.

The design and synthesis of potent and selective indanylmethylpiperidine-based MCHR1 antagonists is reported.Figure optionsDownload as PowerPoint slide