کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1373202 | 981893 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrrolo oximes Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrrolo oximes](/preview/png/1373202.png)
Two series of azanaphthoquinone annelated pyrrolo oximes have been synthesized. The antiproliferative activities of 10 compounds were evaluated on at least four different cell lines. One series of pyrrolo derivatives showed high cytotoxic activity. The effects on cell cycle and caspase activity were investigated. Compounds 9a and 9b showed an accumulation of cells in G2/M phase. Substantial and dose-dependent caspase activity was found after treatment of cells with 9a and 9b. This indicates an apoptosis inducing property of these compounds.
Two novel series of azanaphthoquinone annelated pyrrolo oximes were synthesized by aza-condensation. The cytotoxic evaluation on different cancer cell lines is reported and discussed comparing these two isomers.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 22, 15 November 2007, Pages 6091–6095