Rynaxypyr™: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator

Rynaxypyr™ is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented.

This paper describes the discovery of Rynaxypyr™, the first member from a novel class of anthranilic diamides, with exceptional activity against insects of the order Lepidoptera. Rynaxypyr™ has been found to exhibit its action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. A comparison of Heliothis virescens (Hv) ryanodine receptor activity is made versus insecticidal potency on a series of Lepidoptera, including Hv. Remarkably high differential receptor selectivity is also demonstrated between insect and mammalian cell lines in support of the low mammalian toxicity.Figure optionsDownload as PowerPoint slide