کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1373256 | 981893 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Some new acyclic nucleotide analogues as antiviral prodrugs: Synthesis and bioactivities in vitro
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Some new acyclic nucleotide analogues as antiviral prodrugs: Synthesis and bioactivities in vitro Some new acyclic nucleotide analogues as antiviral prodrugs: Synthesis and bioactivities in vitro](/preview/png/1373256.png)
چکیده انگلیسی
A series of ester analogues of acyclic nucleotide PMPA and PMEA were synthesized as potent antiviral agents. The antiviral evaluation results indicated that bis benzyl ester prodrug of PMPA 5f and bis allyl ester prodrug of PMEA 5g exhibited potent antiviral activities. The IC50 of 5f for HBV was 2.15 μM, and the IC50 of 5g for HIV-1 was 1.61 μM.
A series of new acyclic nucleotide analogues were synthesized and tested for in vitro antiviral activity against HIV/HBV. Most of tested compounds exhibited potent antiviral activity.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 22, 15 November 2007, Pages 6350–6353
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 22, 15 November 2007, Pages 6350–6353
نویسندگان
Yan-bo Tang, Zong-gen Peng, Zong-ying Liu, Yan-ping Li, Jian-dong Jiang, Zhuo-rong Li,