Facile one-pot synthesis of thio and selenourea derivatives: A new class of potent urease inhibitors

A facile, one-pot synthesis of thio and selenourea derivatives from amines using tetrathiomolybdate 1 and tetraselenotungstate 2 as sulfur and selenium transfer reagents, respectively, is reported. The compounds were tested for their activity as urease inhibitors and some of the compounds showed potent activity in the nanomolar range towards jack bean urease.

A facile, one-pot synthesis of thio and selenourea derivatives is reported. Some of the derivatives showed potent inhibitory activity against urease (jack bean) in the nanomolar range.Figure optionsDownload as PowerPoint slide