کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373288 981895 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: Part 1
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: Part 1
چکیده انگلیسی

We investigated proinflammatory cytokine TNFα production inhibitors in order to develop novel anti-inflammatory agents. According to the results, we found that 17, a pyrrole derivative possessing a tetrahydropyridine group at the β-position, showed potent inhibitory activity in vitro (inhibition of lipopolysaccharide (LPS) induced TNFα production in human whole blood, IC50 = 1.86 μM) and in vivo (inhibition of LPS induced TNFα production in mice, ID50 = 5.98 mg/kg).

The synthesis of the proinflammatory cytokine inhibitor 17 (TNFα ID50 = 5.98 mg/kg) is reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 16, 15 August 2009, Pages 4607–4610
نویسندگان
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