Polyethylenimine effectively induces, stabilizes, and regulates intramolecular G-quadruplexes

The interaction between polyethylenimine (PEI) and telomeric DNA was studied. The results demonstrated that PEI could effectively induce, stabilize, and regulate intramolecular G-quadruplexes. The mechanism for these results has been discussed, and was estimated to be condensation effect of PEI.

General scheme of the formation of G-quadruplexes by PEI condensation.Figure optionsDownload as PowerPoint slide