کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373323 981895 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia
چکیده انگلیسی

Niacin is an effective drug for raising HDL cholesterol and reducing coronary risks, but patients show low compliance with treatment due to severe facial flushing upon taking the drug. A series of bicyclic pyrazole carboxylic acids were synthesized and tested for their ability to activate the niacin receptor. One analog, 23, showed improved potency and lacked flushing at doses that effectively altered the lipid profile of rats.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 16, 15 August 2009, Pages 4768–4772
نویسندگان
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