The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists

The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.

The optimisation of diamide 1 to amine 2, a soluble and selective NPY Y2 receptor antagonist with enhanced CNS exposure is described.Figure optionsDownload as PowerPoint slide