کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1373399 | 1500544 | 2010 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Novel and efficient synthesis and antifungal evaluation of 2,3-functionalized cholestane and androstane derivatives Novel and efficient synthesis and antifungal evaluation of 2,3-functionalized cholestane and androstane derivatives](/preview/png/1373399.png)
Synthetic modifications of cholesterol and other traditional steroid molecules have become a promising area for the exploration and development of novel antifungal agents, especially with respect to the development of fatty-acid esters of steroids. In addition, 2,3-functionalized steroids are also compounds with potentially interesting biological properties and proper functionalization of 2,3-steroids can lead to the development of efficient syntheses of building blocks for novel fatty-acid esters of steroids. In this Letter, we outline a novel and efficient approach to the synthesis of 2,3-functionalized cholestane and androstane derivatives and present their promising preliminary antifungal activities against a number of fungal species.
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Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 24, 15 December 2010, Pages 7372–7375