Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.

A series of novel low molecular weight biaryl pyrazole dicarboxamides with good in vitro potency and in vivo efficacy were identified as sodium channel blockers. These state dependent sodium channel blockers were synthesized and evaluated for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.Figure optionsDownload as PowerPoint slide