کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1373423 | 1500544 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain](/preview/png/1373423.png)
چکیده انگلیسی
A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.
A series of novel low molecular weight biaryl pyrazole dicarboxamides with good in vitro potency and in vivo efficacy were identified as sodium channel blockers. These state dependent sodium channel blockers were synthesized and evaluated for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 24, 15 December 2010, Pages 7479–7482
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 24, 15 December 2010, Pages 7479–7482
نویسندگان
Sriram Tyagarajan, Prasun K. Chakravarty, Bishan Zhou, Brett Taylor, Ronsar Eid, Michael H. Fisher, William H. Parsons, Mathew J. Wyvratt, Kathryn A. Lyons, Tracy Klatt, Xiaohua Li, Sanjeev Kumar, Brande Williams, John Felix, Birgit T. Priest,