کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373431 1500544 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of potent, substituted carbazoles as selective androgen receptor modulators (SARMs)
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of potent, substituted carbazoles as selective androgen receptor modulators (SARMs)
چکیده انگلیسی

The synthesis and in vitro binding affinity for a novel series of potent androgen receptor modulators is described. One of the more potent compounds (17, RAD35010) was further characterized in vivo where it restored levator ani weight in castrated male rats to near sham level while having no significant effect on prostate weight.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 24, 15 December 2010, Pages 7516–7520
نویسندگان
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