Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARδ agonists

A novel series of potent and selective PPARδ agonists, para-alkylthiophenoxyacetic acids, was identified. The synthesis and structure–activity relationships are described.

A series of para-alkylthiophenoxyacetic acids was prepared and found to be potent and selective PPARδ agonists.Figure optionsDownload as PowerPoint slide