کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1373491 | 981898 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: [1,3]Diazaheterofused isoindolol derivatives displaying anxiolytic-like effects on mice [1,3]Diazaheterofused isoindolol derivatives displaying anxiolytic-like effects on mice](/preview/png/1373491.png)
Anxiolytic-like effects induced on mice by several compounds with imidazo[2,1-a]isoindolol (II), pyrimido[2,1-a]isoindolol (III) and [1,3]diazepino[2,1-a]isoindolol (IV) structures have been evaluated through the elevated plus-maze test. The evaluation has been based on measuring the spent time and counting the number of entries of mice in the open arms of the maze. Single intraperitoneal administration of imidazoisoindolol IIe and pyrimidoisoindolols IIIa, IIIe and IIIg induced significant increments in these behavioural parameters.
A number of imidazo[2,1-a], pyrimido[2,1-a] and [1,3]diazepino[2,1-a]isoindolols have been tested in the elevated plus-maze test, with significant anxiolytic-like results.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 14, 15 July 2007, Pages 4016–4021