کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373491 981898 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
[1,3]Diazaheterofused isoindolol derivatives displaying anxiolytic-like effects on mice
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
[1,3]Diazaheterofused isoindolol derivatives displaying anxiolytic-like effects on mice
چکیده انگلیسی

Anxiolytic-like effects induced on mice by several compounds with imidazo[2,1-a]isoindolol (II), pyrimido[2,1-a]isoindolol (III) and [1,3]diazepino[2,1-a]isoindolol (IV) structures have been evaluated through the elevated plus-maze test. The evaluation has been based on measuring the spent time and counting the number of entries of mice in the open arms of the maze. Single intraperitoneal administration of imidazoisoindolol IIe and pyrimidoisoindolols IIIa, IIIe and IIIg induced significant increments in these behavioural parameters.

A number of imidazo[2,1-a], pyrimido[2,1-a] and [1,3]diazepino[2,1-a]isoindolols have been tested in the elevated plus-maze test, with significant anxiolytic-like results.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 14, 15 July 2007, Pages 4016–4021
نویسندگان
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