ERβ ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor β-selective ligands

A new class of estrogen receptor beta (ERβ) ligands based on the 6H-chromeno[4,3-b]quinoline scaffold has been prepared. Several C7-substituted analogues displayed high affinity and modest selectivity for ERβ.

A series of 6H-chromeno[4,3-b]quinolines has been prepared and displayed high affinity and moderate selectivity for estrogen receptor beta.Figure optionsDownload as PowerPoint slide