Synthesis and biological evaluation of indolyl glyoxylamides as a new class of antileishmanial agents

A series of indolylglyoxylamide derivatives have been synthesized and evaluated in vitro against amastigote form of Leishmania donovani. Compound 8c has been identified as the most active analog of the series with IC50 value of 5.17 μM and SI value of 31.48, and is several folds more potent than the standard drugs sodium stilbogluconate and pentamidine.

A series of indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity against Leishmania donovani.Figure optionsDownload as PowerPoint slide