کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373519 981901 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis and activity of benzothiazole-based inhibitors of NO production in LPS-activated macrophages
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design, synthesis and activity of benzothiazole-based inhibitors of NO production in LPS-activated macrophages
چکیده انگلیسی

Series of benzothiazoles were synthesized and evaluated their inhibitory activities for NO production in lipopolysaccharide-activated macrophages. The most potent compound was the indole-containing benzothiazole 3c with 4.18 μM of IC50. The mechanistic study suggested that benzothiazoles inhibited NO production by the suppression of iNOS protein and mRNA expression. They also suppressed the expression of COX-2 through the NF-κB inactivation.

Synthesis of series of benzothiazole derivatives and their inhibitory activities on the NO production in lipopolysaccharide-activated macrophages are reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 21, 1 November 2010, Pages 6199–6202
نویسندگان
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