کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1373536 | 981901 | 2010 | 5 صفحه PDF | دانلود رایگان |

The transcription factor NF-κB regulates diverse biological activities, such as inflammatory responses, cell proliferation, and cell survival. Isoflavones are known to have anti-inflammatory and anti-tumor activities, due, in part, to inhibition of NF-κB activity. However, the structural moiety of isoflavones responsible for the inhibition of NF-κB is not clearly understood. In this work, structure–activity relationships of isoflavone derivatives were examined with regard to NF-κB inhibition, using CoMFA and CoMSIA. The results show that substituents at the C-7 and C-4′ positions are crucial for the inhibition of TNFα-induced transcriptional activity of NF-κB.
Isoflavones are known to have anti-inflammatory and anti-tumor activities, due, in part, to inhibition of NF-κB activity. However, the structural moiety of isoflavones responsible for the inhibition of NF-κB is not clearly understood. In this work, structure–activity relationships of isoflavone derivatives were examined with regard to NF-κB inhibition, using CoMFA and CoMSIA.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 21, 1 November 2010, Pages 6277–6281