کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1373585 | 981903 | 2007 | 4 صفحه PDF | دانلود رایگان |
This paper reports on the synthesis, characterisation, and efficiency of a new intravenous conjugate of amphotericin B (AMB). Twelve molecules of AMB were attached to block copolymer poly(ethylene glycol)-b-poly(l-lysine) via pH-sensitive imine linkages. In vitro drug release studies demonstrated the conjugate (Mw = 26,700) to be relatively stable in human plasma and in phosphate buffer (pH 7.4, 37 °C). Controlled release of AMB was observed in acidic phosphate buffer (pH 5.5, 37 °C) with the half-life of 2 min. The LD50 value determined in vivo (mouse) is 45 mg/kg.
A new intravenous of pH-sensitive conjugate of amphotericin B (AMB) has been synthesized and characterised: poly(ethylene glycol)-[b-poly(l-lysine)5]2-(AMB)12 (Mw = 26,700).Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 9, 1 May 2007, Pages 2554–2557