کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373587 981903 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and evaluation of diverse thio avarol derivatives as potential UVB photoprotective candidates
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and evaluation of diverse thio avarol derivatives as potential UVB photoprotective candidates
چکیده انگلیسی

Semisynthesis of 13 new thio avarol derivatives (4–16) and in vitro evaluation on the photodamage response induced by UVB irradiation are described. Their ability to inhibit NF-κB activation and TNF-α generation in HaCaT cells as well as their antioxidant capacity in human neutrophils has also been studied. Among them we have identified two monophenyl thio avarol derivatives (4–5) lacking cytotoxicity which can be considered promising UVB photoprotective agents through the potent inhibition of NF-κB activation with a mild antioxidant pharmacological profile.

Semisynthesis of 13 new thio avarol derivatives (4–16) and in vitro evaluation on the photodamage response induced by UVB irradiation are described. Their ability to inhibit NF-κB activation and TNF-α generation in HaCaT cells as well as their antioxidant capacity in human neutrophils has been also reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 9, 1 May 2007, Pages 2561–2565
نویسندگان
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