کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373596 981903 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors
چکیده انگلیسی

Cholesteryl ester transfer protein is a plasma glycoprotein that transfers cholesterol ester between lipoprotein particles. Inhibition of this protein, in vitro and in vivo, produces an increase in plasma high density lipoprotein cholesterol (HDL-C). This communication will describe the SAR and synthesis of a series of substituted tetrahydroquinoxaline CETP inhibitors from early μ lead to advanced enantiomerically pure analogs.

The SAR and synthesis of a series of substituted tetrahydroquinoxaline CETP inhibitors is described from early lead to advanced analogs.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 9, 1 May 2007, Pages 2608–2613
نویسندگان
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