SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2

Additional SAR for an extended set of structural modification to key moieties of a novel series of selective kappa opioid receptor antagonists based on a previously disclosed series of 8-azabicyclo[3.2.1]octan-3-yloxybenzamides is described.