N,O-Diacyl-4-benzoyl-N-phenylhydroxylamines as photoinduced DNA cleaving agents

Photoinduced homolytic fission of nitrogen–oxygen bond in N,O-diacyl-4-benzoyl-N-phenylhydroxylamines using ⩾310 nm UV light for 10 min produced acylaminyl and acyloxy radicals, which resulted in single strand cleavage of DNA at pH 7.0. Further the DNA cleaving ability of N,O-diacyl-4-benzoyl-N-phenylhydroxylamines found to depend both on its concentration and acyl substituents.

Efficient single strand DNA cleavage by acylaminyl radicals is reported.Figure optionsDownload as PowerPoint slide