کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1373788 | 981906 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Melanin concentrating hormone (MCH) is an important mediator of energy homeostasis and plays role in several disorders such as obesity, stress, depression and anxiety. The synthesis and biological evaluation of novel benzimidazole derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss with a lead compound from this series is exemplified.
The synthesis and biological evaluation of novel benzimidazole derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss is exemplified with compound 22g from this series.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 18, 15 September 2010, Pages 5443–5448
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 18, 15 September 2010, Pages 5443–5448
نویسندگان
Pradip K. Sasmal, Sanjita Sasmal, P. Tirumala Rao, B. Venkatesham, M. Roshaiah, Chandrasekhar Abbineni, Ish Khanna, Vikram P. Jadhav, J. Suresh, Rashmi Talwar, Syed Muzeeb, Jean-Marie Receveur, Thomas M. Frimurer, Øystein Rist, Lisbeth Elster,