کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1373841 | 981908 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A novel class of tetrazole-derived Kv1.5 blockers is disclosed. In in vitro studies, several compounds had IC50s ranging from 180 to 550 nM. In vivo studies indicated that compounds 2f and 2j increased right atrial ERP about 40% without affecting ventricular ERP.
A novel class of tetrazole-derived Kv1.5 blockers is disclosed. In in vitro studies, several compounds had IC50 ranging from 180 to 550 nM. In vivo studies indicated that compounds 2f and 2j increased right atrial ERP about 40% without affecting ventricular ERP.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 24, 15 December 2006, Pages 6213–6218
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 24, 15 December 2006, Pages 6213–6218
نویسندگان
Shengde Wu, Andrew Fluxe, Jim Sheffer, John M. Janusz, Benjamin E. Blass, Ron White, Chris Jackson, Richard Hedges, Michael Murawsky, Bin Fang, Gina M. Fadayel, Michelle Hare, Laurent Djandjighian,