کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373856 981908 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study on synthesis and biological activity of a galactosylated piperazinyl porphyrin
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Study on synthesis and biological activity of a galactosylated piperazinyl porphyrin
چکیده انگلیسی

In order to obtain an carcinoma-selective drug, the synthesis and characterization of 5,10,15,20-tetra[4-(4′-galactosylpiperazinyl)phenyl]porphyrin (TGPP) is reported. The biological activity on cancer cells and the pharmacokinetics are also reported as preliminary results showing a very high liver to skin ratio and short retention time in tissues, and thus promising activity in photodynamic therapy.

5,10,15,20-tetra[4-(4′-Galactosylpiperazinyl)phenyl]porphyrin (TGPP) is reported. The biological activity on cancer cells and the pharmacokinetics are also reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 24, 15 December 2006, Pages 6298–6301
نویسندگان
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