Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents

A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.

A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized.Figure optionsDownload as PowerPoint slide