کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374019 981911 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of indolyl chalcones as antitumor agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of indolyl chalcones as antitumor agents
چکیده انگلیسی

A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b–d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l and 3m were identified as the most potent and selective anticancer agents with IC50 values 0.03 and 0.09 μM, against PaCa-2 cell line, respectively.

A series of indolyl chalcones were synthesized and evaluated for their in vitro anti-proliferative activities against various cancer cell lines.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 13, 1 July 2010, Pages 3916–3919
نویسندگان
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