کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374076 981912 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides
چکیده انگلیسی

A series of bis-oxy cyclophane diamides with bis(aminomethyl)m-terphenyl as spacer have been synthesized and characterized from spectral and analytical data. All the cyclophane diamides exhibit better anti-arthritic activity than the reference drug viz. diclofenac sodium. Some of the cyclophane diamides exhibit good anti-inflammatory activity. The cyclophane amide 4 and 5 do not show any evidence of mutagenicity and cytotoxicity.

Series of bis-oxy cyclophane diamides with m-terphenyl diamine as spacer have been synthesized. All the cyclophane diamides show good anti-inflammatory activity and some of the cyclophane diamides exhibited better anti-arthritic activity than the reference drug viz. diclofenac sodium. The cyclophane amide 4 and 5 do not show any evidence of mutagenicity and cytotoxicity in the assays employed.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 11, 1 June 2012, Pages 3770–3775
نویسندگان
, , ,