کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1374076 | 981912 | 2012 | 6 صفحه PDF | دانلود رایگان |

A series of bis-oxy cyclophane diamides with bis(aminomethyl)m-terphenyl as spacer have been synthesized and characterized from spectral and analytical data. All the cyclophane diamides exhibit better anti-arthritic activity than the reference drug viz. diclofenac sodium. Some of the cyclophane diamides exhibit good anti-inflammatory activity. The cyclophane amide 4 and 5 do not show any evidence of mutagenicity and cytotoxicity.
Series of bis-oxy cyclophane diamides with m-terphenyl diamine as spacer have been synthesized. All the cyclophane diamides show good anti-inflammatory activity and some of the cyclophane diamides exhibited better anti-arthritic activity than the reference drug viz. diclofenac sodium. The cyclophane amide 4 and 5 do not show any evidence of mutagenicity and cytotoxicity in the assays employed.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 11, 1 June 2012, Pages 3770–3775