کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1374098 | 981913 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
A series of 2-aminoquinoline compounds was prepared and evaluated in MCH1R binding and functional antagonist assays. Small dialkyl, methylalkyl, methylcycloalkyl, and cyclic amines were tolerated at the quinoline 2-position. The in vivo efficacy of compound 12 was explored and compared to that of a related inactive analog to determine their effects on food intake and body weight in rodents.
Structure–activity relationships and in vivo activity of 2-aminoquinoline MCH1R antagonists are reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 20, 15 October 2006, Pages 5270–5274
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 20, 15 October 2006, Pages 5270–5274
نویسندگان
Jinlong Jiang, Myle Hoang, Jonathan R. Young, Danny Chaung, Ronsar Eid, Cherilyn Turner, Peter Lin, Xinchun Tong, Junying Wang, Carina Tan, Scott Feighner, Oksana Palyha, Donna L. Hreniuk, Jie Pan, Andreas W. Sailer, Douglas J. MacNeil, Andrew Howard,