کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374098 981913 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists
چکیده انگلیسی

A series of 2-aminoquinoline compounds was prepared and evaluated in MCH1R binding and functional antagonist assays. Small dialkyl, methylalkyl, methylcycloalkyl, and cyclic amines were tolerated at the quinoline 2-position. The in vivo efficacy of compound 12 was explored and compared to that of a related inactive analog to determine their effects on food intake and body weight in rodents.

Structure–activity relationships and in vivo activity of 2-aminoquinoline MCH1R antagonists are reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 20, 15 October 2006, Pages 5270–5274
نویسندگان
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