کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374163 981914 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhancement of DNA cleavage activity of an unnatural ferrocene-amino acid conjugate
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Enhancement of DNA cleavage activity of an unnatural ferrocene-amino acid conjugate
چکیده انگلیسی

The nucleolytic activity of an unnatural ferrocenyl amino acid can be significantly enhanced under reducing or Fenton conditions while exploiting different mechanisms of DNA cleavage. In addition, results from high resolution electrophoresis indicate that the ferrocenyl amino acid exhibits non-sequence specific cleavage of the DNA backbone.

The nucleolytic activity exhibited by an unnatural ferrocenyl amino acid is non-specific along the DNA backbone and can be significantly enhanced under reducing and Fenton conditions.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 6, 15 March 2009, Pages 1614–1617
نویسندگان
, ,