کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374281 981916 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Methylene amine substituted arylindenopyrimidines as potent adenosine A2A/A1 antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Methylene amine substituted arylindenopyrimidines as potent adenosine A2A/A1 antagonists
چکیده انگلیسی

A novel series of arylindenopyrimidines were identified as A2A and A1 receptor antagonists. The series was optimized for in vitro activity by substituting the 8- and 9-positions with methylene amine substituents. The compounds show excellent activity in mouse models of Parkinson’s disease when dosed orally.

A novel series of arylindenopyrimidines were identified as A2A and A1 receptor antagonists. The series was optimized for in vitro activity by substituting the 8- and 9-positions with methylene amine substituents. The compounds show excellent activity in mouse models of Parkinson’s disease when dosed orally.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 9, 1 May 2010, Pages 2864–2867
نویسندگان
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