Fused heterocyclic M1 positive allosteric modulators

Fused aromatics such as naphthalene were identified as highly potent and CNS penetrant M1 positive allosteric modulators during an SAR study to replace the phenyl B-ring linkage.

Fused aromatics such as naphthalene were identified as highly potent and CNS penetrant M1 positive allosteric modulators during an SAR study to replace the phenyl B-ring linkage.Figure optionsDownload as PowerPoint slide