Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-d-arabino heptulosonate 7-phosphate synthase

The first mechanism-based inhibitor of a 3-deoxy-d-arabino heptulosonate 7-phosphate (DAH7P) synthase has been synthesised in 12 steps from d-arabinose, and has been found to be a very slow binding inhibitor of Escherichia coli DAH7P synthase.

The first mechanism-based inhibitor of a 3-deoxy-d-arabino heptulosonate 7-phosphate (DAH7P) synthase has been synthesised in 12 steps from d-arabinose, and has been found to be a very slow binding inhibitor of Escherichia coli DAH7P synthase.Figure optionsDownload as PowerPoint slide