Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate

A conjugate of DHA and doxorubicin (DHA–Dox) was synthesized, and its antitumor activity was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia and B16 melanoma. DHA–Dox showed a greatly improved antitumor efficacy compared to free doxorubicin.

Synthesis of a DHA and doxorubicin conjugate is reported.Figure optionsDownload as PowerPoint slide