کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374414 981918 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents
چکیده انگلیسی

We have successfully identified a number of novel MTP inhibitors with single digit nanomolar potency. Analogues 10aq and 10dq demonstrated in vivo efficacy in a murine gut retention assay.

Structure activity relationship (SAR) studies of a novel class of MTP inhibitors are described. A number of novel MTP inhibitors have been identified with single digit nanomolar potency. Analogues 10aq and 10dq demonstrated in vivo efficacy in a murine gut retention assay.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 11, 1 June 2006, Pages 3039–3042
نویسندگان
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