کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374421 981918 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
3,4-Fused cyclohexyl sulfones as γ-secretase inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
3,4-Fused cyclohexyl sulfones as γ-secretase inhibitors
چکیده انگلیسی

The 3,4-fused sulfamides, sulfonamides and sulfone have been identified as highly potent γ-secretase inhibitors. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain Aβ in transgenic mouse models and thus have potential as possible treatments for Alzheimer’s disease.

The identification of a potent γ-secretase inhibitor, for example (ED50 = 0.06 nM), is reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 11, 1 June 2006, Pages 3073–3077
نویسندگان
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