Synthesis and antimicrobial activity of some new pyrazole derivatives containing a ferrocene unit

A series of new imines and amines have been synthesized by condensation of 1H-3-ferrocenyl-1-phenylpyrazole-4-carboxaldehyde with the corresponding amines, followed by reduction with sodium borohydride. The synthesized compounds have been screened for their in vitro antimicrobial activity against 11 bacteria and three fungal/yeast strains, using disc diffusion and broth microdilution susceptibility assays. They have shown a wide range of activities, from completely inactive to the highly active compounds.

Nine imines and the corresponding amines were synthesized and screened for their in vitro antimicrobial activity against 11 bacteria and three fungal/yeast strains. One of amines (R = tert-butyl) showed the higher activity in comparison with widely used tetracycline.Figure optionsDownload as PowerPoint slide