Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation

An IKKβ inhibitor reported to block NF-κB transcriptional activities in Jurkat T cells, was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling pathway independent of IKKβ in HUVEC cells.

A reported IKKβ inhibitor to inhibit NF-κB transcriptional activities in Jurkat T cells was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling independent to IKKβ in HUVEC cells.Figure optionsDownload as PowerPoint slide