کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374588 981921 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design of potent and selective GSK3β inhibitors with acceptable safety profile and pharmacokinetics
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design of potent and selective GSK3β inhibitors with acceptable safety profile and pharmacokinetics
چکیده انگلیسی

From potent and selective inhibitors of GSK3β displaying CYP1A2 inhibition and poor PK properties, mostly linked to metabolic instability and in vivo hydrolysis of the amide bond, we were able to obtain safe and orally available inhibitors with good half lives.

From potent and selective inhibitors of GSK3β displaying CYP1A2 inhibition and poor PK properties mostly linked to metabolic instability and in vivo hydrolysis of the amide bond, we were able to obtain safe and orally available inhibitors with good half lives.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 7, 1 April 2010, Pages 2344–2349
نویسندگان
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