کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1374588 | 981921 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design of potent and selective GSK3β inhibitors with acceptable safety profile and pharmacokinetics
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
From potent and selective inhibitors of GSK3β displaying CYP1A2 inhibition and poor PK properties, mostly linked to metabolic instability and in vivo hydrolysis of the amide bond, we were able to obtain safe and orally available inhibitors with good half lives.
From potent and selective inhibitors of GSK3β displaying CYP1A2 inhibition and poor PK properties mostly linked to metabolic instability and in vivo hydrolysis of the amide bond, we were able to obtain safe and orally available inhibitors with good half lives.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 7, 1 April 2010, Pages 2344–2349
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 7, 1 April 2010, Pages 2344–2349
نویسندگان
Dominique Lesuisse, Gilles Tiraboschi, Alain Krick, Pierre-Yves Abecassis, Gilles Dutruc-Rosset, Didier Babin, Frank Halley, Fabienne Châtreau, Sylvette Lachaud, Alain Chevalier, Dominique Quarteronet, Marie-Claude Burgevin, Céline Amara,