کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1374643 | 981922 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Penta-substituted benzimidazoles as potent antagonists of the calcium-sensing receptor (CaSR-antagonists)
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Penta-substituted benzimidazoles as potent antagonists of the calcium-sensing receptor (CaSR-antagonists) Penta-substituted benzimidazoles as potent antagonists of the calcium-sensing receptor (CaSR-antagonists)](/preview/png/1374643.png)
چکیده انگلیسی
A series of novel benzimidazole derivatives has been designed via a scaffold morphing approach based on known calcilytics chemotypes. Subsequent lead optimisation led to the discovery of penta-substituted benzimidazoles that exhibit attractive in vitro and in vivo calcium-sensing receptor (CaSR) inhibitory profiles. In addition, synthesis and structure–activity relationship data are provided.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 17, 1 September 2010, Pages 5161–5164
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 17, 1 September 2010, Pages 5161–5164
نویسندگان
Marc Gerspacher, Eva Altmann, René Beerli, Thomas Buhl, Ralf Endres, Rainer Gamse, Jacques Kameni-Tcheudji, Michaela Kneissel, Karl Heinz Krawinkler, Martin Missbach, Alfred Schmidt, Klaus Seuwen, Sven Weiler, Leo Widler,