Heteroaromatic side-chain analogs of pregabalin

A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein.

As part of a program to identify the scope of substituents recognized by the α2-δ protein, a series of heteroaromatic analogs, 2, of pregabalin, 1, has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein.Figure optionsDownload as PowerPoint slide