کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374709 981923 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-Plasmodium activity of imidazole–dioxolane compounds
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Anti-Plasmodium activity of imidazole–dioxolane compounds
چکیده انگلیسی

A series of imidazole–dioxolane compounds, which we hypothesize should bind to heme and thus interfere with heme catabolism in the parasite, were assayed for inhibitory activity in Plasmodium falciparum cultures and the results were compared to those obtained with Chinese hamster ovary (CHO) cells. The majority of the compounds displayed a similar ratio of inhibitory activity in the two culture systems; however, a number of the compounds tested showed promising anti-Plasmodium activity. The mechanism of action of these compounds remains unclear, however their inability to act synergistically with chloroquine suggests that, if they are inhibiting heme detoxification, they do so in a manner that does not complement the action of chloroquine.

A series of imidazole–dioxolane compounds were assayed for inhibitory activity in Plasmodium falciparum cultures.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 9, 1 May 2006, Pages 2396–2406
نویسندگان
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