Studies on synthesis and evaluation of quantitative structure-activity relationship of 10-methyl-6-oxo-5-arylazo-6,7-dihydro-5H-[1,3]azaphospholo[1,5-d][1,4]benzodiazepin-2-phospha-3-ethoxycarbonyl-1-phosphorus dichlorides

A series of [1,3]azaphospholo [1,5-d][1,4] benzodiazepin-3-ethoxycarbonyl-1-phosphorus dichlorides have been synthesized. Their chemical structures are confirmed by spectral and elemental analysis data. These synthesized compounds are subjected to antimicrobial activity using ampicillin and clotrimazole as reference antibiotic drugs. Quantitative structure-activity relationship (QSAR) investigations are applied to find the correlation between evaluated biological activities and physicochemical descriptors. Significant correlations are obtained between biological activity and the polarizability parameter (MR) of the compounds studied.