کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374758 981924 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure–activity relationships of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the treatment of cough
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Structure–activity relationships of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the treatment of cough
چکیده انگلیسی

A series of 3-axial-aminomethyl-N-benzhydryl-nortropane analogs have been synthesized and identified to bind to the nociceptin receptor with high affinity. Many of these analogs showed high binding selectivity over classic opioid receptors such as μ receptor. The synthesis and structure–activity relationships around the C-3 nortropane substitution are described. Selected compounds with potent oral antitussive activity in the guinea pig model are disclosed.

A series of 3-disubstituted-nortropane analogs have been identified to bind to the nociceptin receptor with high affinity. The syntheses and structure–activity relationships of these analogs are described.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 24, 15 December 2008, Pages 6340–6343
نویسندگان
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