کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1374871 | 981927 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and evaluation of d-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and evaluation of d-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors Synthesis and evaluation of d-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors](/preview/png/1374871.png)
چکیده انگلیسی
In the recent past sugar-derived cyclopropylamines were proposed as structurally new glycosidase inhibitors. In this Letter we report our efforts in the synthesis of a set of α-glucose configured oxabicyclo[4.1.0] heptanes, based on this hypothesis, bearing an amine substituent on the propyl ring and reveal that their inhibitory potential towards a range of mammalian glucosidases is modest.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 23, 1 December 2009, Pages 6600–6603
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 23, 1 December 2009, Pages 6600–6603
نویسندگان
Martijn D.P. Risseeuw, Richard J.B.H.N. van den Berg, Wilma E. Donker-Koopman, Gijs A. van der Marel, Johannes M.F.G. Aerts, Mark Overhand, Herman S. Overkleeft,